Diastolic Cardiac Insufficiency

Sanofi, ScienceProd-Paris

Diastolic Cardiac Insufficiency is characterized by the thickening of the left ventricle and improper filling of the left venticular chamber; symptoms triggered by the Angiotensin - Aldosterone - Renin system. This system is responsible for the release of aldosterone, noradrenaline,  

and angiotensin II; hormones that bind to fibroblasts, releasing collagen and increasing myofibril rigidity. The thickened ventricular wall leads to sluggishness  in pumping, thus creating poor circulation and difficulties in oxygen distribution to the tissues.

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