Natrecor; hBNP MOA
Scios, Adair Greene Advertising, Inc.
Natracor® (Neseritide or hBNP) treats congestive
heart failure triggered by two neuro-hormonal systems; the Renin - Angiotensin - Aldosterone system
and the Sympathetic Nervous System. These systems cause sodium and fluid retention and vaso-constriction. hBNP, a counter
regulatory hormone, binds to Guanylate cyclase receptors to
reverse the adverse effects of the two systems mentioned above, reducing the risk of congestive heart failure. In its
natural form it is found as part of a counter regulatory hormonal system
called the Natriuretic Peptide System.
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